¹Faculty of Animal Science, Universitas Gadjah Mada, Indonesia

²Department of Animal Science, Faculty of Agriculture, Universitas Sebelas Maret, Indonesia

Email: prastowo@staff.uns.ac.id

Our previous study found five candidate genes associated with economic traits in Madura Cattle, consist of Insulin-like growth factor-1 (IGF-1), Growth hormone (GH), Growth hormone receptor (GHR), Myostatin (MSTN), and Leptin (LEP). This paper aimed to identify protein to protein interaction of genes responsible for economic traits of Madura Cattle. In silico study was done using STRING v.11.5 with Bos taurus IGF1, GH1, GHR, MSTN and LEP as input analysis. Results show 24 biological processes, 3 molecular functions and 6 KEGG pathways as potential protein interaction. All genes involved in six biological processes i.e. response to hormone, response to oxygen-containing compound, cell surface receptor signaling pathway, regulation of signal transduction, positive regulation of cellular metabolic process, and positive regulation of macromolecule metabolic process. Five genes were predicted as functional partner genes, namely Leptin receptor (LEPR), Tyrosine-protein kinase receptor (INSR), Activin receptor type-2b precursor (ACVR2B), Insulin-like growth factor 1 receptor (IGF1R), and Insulin-like growth factor-binding protein 3 (IGFBP3). Based on the results, we can demonstrate protein to protein interaction of IGF-1, GH, GHR, MSTN and LEP genes which are potentially related to each other. Association study between mentioned genes with economic traits on Madura Cattle is required to validate the interaction.